Table 4.
Multivariable logistic regression predicting high IFN score in JDM patients
| Parameter | Estimate | Standard error | p value | Odds ratio | 95% confidence interval | |
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| Constant | 23.247 | 8.968 | 0.010 | – | – | – |
| Total MMT score | − 0.099 | 0.037 | 0.007 | 0.91 | 0.84 | 0.97 |
| LDH | − 0.013 | 0.007 | 0.073 | 0.99 | 0.97 | 1.00 |
| Skeletal VAS | 1.184 | 0.550 | 0.031 | 3.27 | 1.11 | 9.60 |
High and low 28 interferon-regulated gene (IRG) score is defined by above and below 48.9, 95th percentile of healthy controls [22]. Backwards stepwise regression was performed (alpha < 0.15). p values < 0.05 are bolded. With the odds ratio, 1 is 1 point in the MMT score, LDH value, or 1 point on 10 point scale of skeletal VAS
Abbreviations: Total MMT score 26 muscle manual muscle testing (0–260), LDH lactate dehydrogenase, skeletal VAS Myositis Disease Activity Assessment Tool Skeletal disease activity visual analog scale