Table 4.
Characteristics of Patients based on the PAH Diagnosis by RHC (n = 614)
| Characteristics | No PAH (n = 203) | PAH (n = 411) | P value |
|---|---|---|---|
| Age at Enrollment (years) [mean ± SD] | 32.2 ± 12.0 | 36.4 ± 12.9 | < 0.001 |
| Gender [n (%)] | |||
| Males | 42 (20.7) | 75 (18.2) | 0.469 |
| Females | 161 (79.3) | 336 (81.8) | |
| Body Mass Index [mean ± SD] | 20.2 ± 3.4 | 19.5 ± 6.9 | 0.136 |
| Blood Pressure (mmHg) [mean ± SD] | |||
| Systolic | 111.4 ± 15.1 | 110.7 ± 18.8 | 0.678 |
| Diastolic | 73.4 ± 10.9 | 72.9 ± 11.9 | 0.698 |
| Oxygen Saturation (%)[mean ± SD]a | 97.4 ± 3.2 | 94.8 ± 5.5 | < 0.001 |
| 6 Minute Walk Distance (meter)[mean ± SD]b | 393.9 ± 82.1 | 336.3 ± 99.7 | < 0.001 |
| WHO Functional Class [n(%)]c | < 0.001 | ||
| I | 122 (60.4) | 136 (34.0) | |
| II | 70 (34.7) | 207 (51.8) | |
| III-IV | 10 (5.0) | 57 (14.2) | |
| Hemoglobin (g/dL) [mean ± SD]d | 13.5 ± 1.9 | 14.1 ± 2.2 | 0.006 |
| Hematocrit (%) [mean ± SD]e | 40.2 ± 4.9 | 42.2 ± 6.5 | < 0.001 |
| NTproBNP (pg/mL) [median (IQR)]f | 121.5 (57.1–218.1) | 774.0 (242.8–2022.3) | < 0.001 |
| Congenital Anomalies [n (%)] | 0.005 | ||
| ASD | 166 (81.8) | 367 (89.3) | |
| VSD | 26 (12.8) | 17 (4.1) | |
| PDA | 10 (4.9) | 21 (5.1) | |
| Multiple defect | 1 (0.5) | 4 (1.0) | |
| AP window | 0 (0) | 1 (0.2) | |
| AVSD | 0 (0) | 1 (0.2) | |
a data of 488 patients, b data of 442 patients, c data of 602 patients, d data of 439 patients, e data of 444 patients, f data of 294 patients,
PAH pulmonary artery hypertension, ASD: atrial septal defect, VSD ventricular septal defect, PDA patent ductus arteriosus, AP aortopulmonal, AVSD atrioventricular septal defects, WHO world health organisation