Table 1.
Selection of studies comparing SCZ and BD in terms of GM volume using voxel-based approaches
| Study | No. of SCZ patients | No. of BD patients | Study type | Findings |
|---|---|---|---|---|
| Farrow et al. (2005) | 25 (2 years after psychosis onset) | 8 (BD type I, 2 years after psychosis onset) | SC | BD < SCZ: left uncus, middle temporal gyrus and amygdala, right lingual gyrus and left cerebellum. SCZ < BD: left precentral/inferior frontal gyrus, right medial frontal gyrus, bilateral inferior and middle frontal gyrus |
| McDonald et al. (2005) | 25 | 37 (BD type I, all with lifetime psychosis) | SC | SCZ < BD: bilateral inferior and middle frontal gyri, middle and superior temporal gyri, insula, precentral gyrus, precuneus and caudate nucleus. Right postcentral gyrus, amygdala, hippocampus, parahippocampal gyrus, putamen and thalamus |
| Molina et al. (2011) | 38 | 19 (BD type I, 10 with lifetime psychosis) | SC | SCZ < BD: right anterior and posterior cerebellum, right pulvinar thalamus, bilateral medial frontal cortex, left precentral frontal cortex. BD < SCZ: bilateral anterior cerebellar lobe, left anterior cingulate cortex |
| Brown et al. (2011) | 17 | 15 (BD type I) | SC | SCZ < BD: right hippocampus, putamen and amygdala |
| Cui et al. (2011) | 23 | 24 (BD type I) | SC | SCZ v. BD: no significant differences |
| Ivleva et al. (2012) | 19 | 17 (BD type I, all with lifetime psychosis) | SC | SCZ < BD: left precuneus and left lingual gyrus |
| Yuksel et al. (2012) | 58 (21 with schizoaffective disorder) | 28 (BD type I, all with lifetime psychosis) | SC | SCZ < BD: bilateral subgenual cortex |
| Ivleva et al. (2013) | 146 | 115 (BD type I, all with lifetime psychosis) | MC | SCZ < BD: frontal, temporal, parietal, occipital, cingulate cortex, insula, thalamus, basal ganglia and cerebellum |
| Nenadic et al. (2015a, b) | n = 34 | 17 (BD type I, all with lifetime psychosis) | SC | SCZ < BD: bilateral medial, dorsolateral and ventrolateral prefrontal cortex, thalamus, insula, superior and medial temporal lobes, posterior hippocampus |
| Amann et al. (2016) | n = 45 (20 with acute symptoms, 25 stabilised) | n = 45 (BD type I, 32 with lifetime psychosis) | SC | SCZ < BD: left and right cerebellum |
SC, single centre; MC, multi centre; SCZ, schizophrenia; BD, bipolar disorder; GM, grey matter.