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Kinetic and dissociation constants for binding of SR-F1 to immobilized C1q.
| SR-F1 variant | ka (M−1 s−1) | kd (s−1)a | KD (nM)a | t1/2 (s)b |
|---|---|---|---|---|
| (20-421) | 6.84 ± 0.99 × 103 | 1.26 ± 0.20 × 10−3 | 186 ± 21 | 550 |
| (20-353) | 7.00 ± 2.41 × 104 | 2.09 ± 0.44 × 10−3 | 32.4 ± 6.4 | 331 |
| (20-221) | 1.85 ± 0.39 × 105 | 3.03 ± 0.74 × 10−3 | 17.7 ± 0.9 | 229 |
Values are the means ± SE of three experiments on different surfaces.
Half-lives of complexes were determined from the kd values using the formula t1/2 = ln2/kd.
