Table 5.
Drug treatment factors associated with QTc prolongation in patients exposed to antidepressant drugs (model 3): linear regression analysis (bootstrapped 95% CIs)
| Explanatory variable | Coefficient* (bias corrected 95% CI) | z value | p value |
|---|---|---|---|
| Two or more AD drugs (no = 0, yes = 1) | −1.73 (−8.70–5.22) | −0.49 | 0.625 |
| AD dose (PDD/DDD, continuous variable) | 0.02 (−1.95–2.00) | 0.02 | 0.983 |
| SSRIs (no = 0, yes = 1) | 2.16 (−1.76–6.08) | 1.08 | 0.280 |
| Citalopram (no = 0, yes = 1) | 5.77 (0.31–11.23) | 2.07 | 0.038 |
| Citalopram dose (PDD/DDD, continuous variable) | 3.44 (0.71–6.16) | 2.48 | 0.013 |
| Escitalopram (no = 0, yes = 1) | 2.21 (−3.74–8.17) | 0.73 | 0.467 |
| Escitalopram dose (PDD/DDD, continuous variable) | 3.36 (−1.21–7.94) | 1.44 | 0.150 |
| Methadone (no = 0, yes = 1) | 4.68 (−18.62–27.99) | 0.39 | 0.694 |
| Any AP use in addition to AD drugs (no = 0, yes = 1) | 3.20 (−2.54–8.95) | 1.09 | 0.274 |
| Second-generation APs in addition to AD drugs (no = 0, yes = 1) | −1.69 (−6.52–3.14) | −0.69 | 0.492 |
| Haloperidol in addition to AD drugs (no = 0, yes = 1) | 9.23 (0.56–17.90) | 2.09 | 0.037 |
| Risperidone in addition to AD drugs (no = 0, yes = 1) | −7.59 (−18.46–3.26) | −1.37 | 0.171 |
| Clozapine in addition to AD drugs (no = 0, yes = 1) | 1.99 (−17.99–21.98) | 0.20 | 0.845 |
| Olanzapine in addition to AD drugs (no = 0, yes = 1) | 0.52 (−7.29–8.34) | 0.13 | 0.895 |
| Quetiapine in addition to AD drugs (no = 0, yes = 1) | −1.78 (−6.74–3.16) | −0.71 | 0.479 |
| Ziprasidone in addition to AD drugs (no = 0, yes = 1) | 8.87 (−23.73–41.48) | 0.53 | 0.594 |
| Paliperidone in addition to AD drugs (no = 0, yes = 1) | −5.10 (−39.89–29.69) | −0.29 | 0.774 |
| Aripiprazole in addition to AD drugs (no = 0, yes = 1) | −10.22 (−22.92–2.46) | −1.58 | 0.114 |
| Asenapine in addition to AD drugs (no = 0, yes = 1) | −9.70 (−28.55–9.13) | −1.01 | 0.313 |
CI, confidence interval; AP, antipsychotic drugs; AD, antidepressant drugs; SSRI, selective serotonin-reuptake inhibitors.
*
Adjusted for the following variables: sex, age, psychosis or related disorder, heart rate, alcohol or substance use, cardiovascular disease, cardiovascular drug treatment, drug overdose, inpatients.