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. 2020 Mar 31;11:299. doi: 10.3389/fphys.2020.00299

FIGURE 2.

FIGURE 2

Femoral cortical bone loss in Cx43 transgenic but not in WT mice following HLU. B.Ar/T.Ar (A), B.Ar (B), and Ct.Th (C) are decreased in R76W and Δ130–136 transgenic mice; BMD (D) is decreased only in R76W mice; and Ec.Pr (E) and M.Ar (F) are increased only in Δ130–136 mice; (G) μCT images of femoral cortical microstructure. Three-point bending assay showing stiffness (H) is decreased in WT and R76W mice; elastic modulus (I) and maximum stress (J) did not differ significantly between control and HLU. Comparisons via two-way with Bonferroni test (A–F,H–J). Data represent the means ± SD. n = 6–10/group. *P < 0.05, **P < 0.01. HLU, hindlimb unloading; WT, wild-type; R, R76W; Δ, Δ130–136; B.Ar, bone area; T.Ar, total area; Ct.Th, cortical thickness; BMD, bone mineral density; Ec.Pr, inner perimeter; M.Ar, marrow area; μCT, micro-computed tomography.