Table 3.

Cox Proportional Hazards Regression for Predictors of Unsuccessful Treatment Outcome (Death, Treatment Failure, and Tuberculosis Recurrence)

	Participants		Hazard Ratio (95% CI)
Factor by Population	Total, No.	Poor Outcome, No. (%)	Crude	Adjusted
Primary analysis population
HIV status
Positive	102	18 (18)	6.14 (3.12–12.10)a	4.79 (2.10–10.91)a,b
Negative	445	17 (4)	Reference	Reference
Baseline weight (per 1-kg increase)	547	35 (6)	1.0 (.99–1.03)	0.99 (.96–1.02)c
Weight at 2 mo (per 1-kg increase)	547	35 (6)	0.97 (.94–1.01)	0.97 (.94–1.01)c
Absolute weight change (per 1-kg increase)	547	35 (6)	0.83 (.77–0.89)a	0.88 (.81–0.95)a,d
Relative weight change (per 1% increase)	547	35 (6)	0.89 (.86–0.93)a	0.92 (.88–0.96)a,d
Full population
HIV status
Positive	117	25 (21)	5.63 (3.20–9.90)a	3.88 (1.81–8.34)a,b
Negative	481	24 (5)	Reference	Reference
Baseline weight (per 1-unit increase)	598	49 (8)	0.98 (.96–1.01)	0.98 (.95–1.01)c

Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus.

^aStatistically significant at P < .05.

^bAdjusted for sex and hemoglobin level.

^cAdjusted for HIV status, and sex.

^dAdjusted for baseline weight, HIV status, and sex.