Figure 1.

Distribution of AIPmut vs AIPneg PitNETs according to age at onset (A) and to clinical diagnosis (B). Numbers above columns represent percentage of patients. We note that the two AIPmut cases with first symptoms in the 5th and 6th decade, both had macroprolactinomas, 1 presenting with apoplexy. ACTHoma, ACTH-secreting adenoma or Cushing’s disease; AIPmut, AIP mutation-positive; AIPneg, AIP mutation-negative; PitNET NS, pituitary neuroendocrine tumor not specified; NF-PitNET, non-functioning PitNET; PRLoma, prolactinoma; TSHoma, thyrotropinoma; yr, years.