Table 2.
AIPmut and AIPneg FIPA kindreds according to pituitary tumor types
| AIPmut kindreds | AIPneg kindreds | Total | |
|---|---|---|---|
| PitNET types within the same kindred | n = 37 | n = 318 | n = 355 |
| ACTHoma only | 0 | 7 (2.2) | 7 (2.0) |
| ACTHoma + FSHoma | 0 | 1 (0.3) | 1 (0.3) |
| ACTHoma + GHoma | 0 | 7 (2.2) | 7 (2.0) |
| ACTHoma + NF-PitNET | 0 | 1 (0.3) | 1 (0.3) |
| ACTHoma + NF-PitNET + PitNET NS | 0 | 1 (0.3) | 1 (0.3) |
| ACTHoma + NF-PitNET + PRLoma | 0 | 1 (0.3) | 1 (0.3) |
| ACTHoma + PitNET NS | 0 | 2 (0.6) | 2 (0.6) |
| ACTHoma + PRLoma | 0 | 8 (2.5) | 8 (2.3) |
| GHoma only | 19 (51.4) | 68 (21.4) | 87 (24.5) |
| GHoma + NF-PitNET | 8 (21.6) | 25 (7.9) | 33 (9.3) |
| GHoma + NF-PitNET + PRLoma | 1 (2.7) | 4 (1.3) | 5 (1.4) |
| GHoma + PitNET NS | 0 | 19 (6.0) | 19 (5.3) |
| GHoma + PitNET NS + PRLoma | 0 | 1 (0.3) | 1 (0.3) |
| GHoma + PRLoma | 8 (21.6) | 45 (14.2) | 53 (14.9) |
| NF-PitNET only | 0 | 24 (7.5) | 24 (6.8) |
| NF-PitNET + PitNET NS | 0 | 14 (4.4) | 14 (3.9) |
| NF-PitNET + PRLoma | 0 | 24 (7.5) | 24 (6.8) |
| PRLoma only | 1 (2.7) | 47 (14.8) | 48 (13.5) |
| PRLoma + FSHoma | 0 | 1 (0.3) | 1 (0.3) |
| PRLoma + PitNET NS | 0 | 18 (5.7) | 18 (5.1) |
Data are shown as n (%).
Abbreviations: ACTHoma, ACTH-secreting adenoma or Cushing’s disease; AIPmut, AIP mutation-positive; AIPneg, AIP mutation-negative; FSHoma, FSH-secreting adenoma; GHoma, GH-secreting adenoma or somatotropinoma (this category includes acromegaly and gigantism cases); PitNET NS, pituitary neuroendocrine tumor not specified; NF-PitNET, nonfunctioning PitNET; PRLoma, prolactinoma.