India 1988.
Methods | Please see bias table below. | |
Participants | 199 women with eclampsia. | |
Interventions | MgSO4: modified Pritchard's regimen. After the loading dose administered, the IM maintenance dose was administered every 6 hours instead of 4. Lytic cocktail: Menon's regimen. No further information given. |
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Outcomes | Women: maternal mortality, maternal morbidity, coma > 72 hours, oliguria, anuria, acute renal failure, DIC, respiratory infection, abruptio placentae, atonic PPH, vulval hematoma, postpartum psychosis, cardiac arrest, shock, UTI, bed sore, thrombophlebitis. Babies: stillbirth, neonatal death, Apgar score < 7, < 4, RDS, meconium aspiration syndrome, septicaemia, hyperbilirubinemia, intracranial haemorrhage, bronchopnuemonia, diarrhoea. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Described as "randomly allocated to two treatment regimens." No further information given. |
Allocation concealment? | Unclear risk | No information given. |
Blinding? All outcomes | High risk | Blinding of the 2 treatment regimens was not possible. Outcome assessment was by the attending clinician, but outcomes used were largely objective, reducing potential for bias. |
Incomplete outcome data addressed? All outcomes | Unclear risk | Data are presented as percentages only. |