Peterman 1997.
Methods |
Setting: public health services in Broward County, Florida; Tampa, Florida; Patterson, New Jersey, US Enrolment: participants were enrolled from December 1990 to March 1993 Follow up: no follow‐up recorded of index patients |
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Participants | 1966 index patients with syphilis were randomised, 1042 male and 924 female Inclusion criteria
Exclusion criteria
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Interventions | After syphilis diagnosis all index patients were interviewed by DIS to identify sexual partners Contract referral (n = 586) Index patient to notify partners within 2 days, or a DIS would notify them on the third day Provider referral (n = 742) Partner notified immediately by DIS and referral of partner for testing Provider referral and field test (n = 638) Partner notified immediately by DIS who could draw blood for testing in the field, if it seemed unlikely for partner to come in for testing |
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Outcomes |
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Notes | Details on ethical approval not given | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Individual index patients were randomly assigned. Every day the study co‐ordinator at each site generated a list of assignments by using a random number table. The total number of patients in each arm differed significantly from 742, 638 and 586, this raises suspicion about whether randomisation was performed appropriately |
Allocation concealment (selection bias) | High risk | The assignment was known to the interviewer before contact with the patient and the method was sequentially adapted by the interviewer |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Outcome data were available for all partners of index patients |
Selective reporting (reporting bias) | Low risk | Same outcomes in methods section compared to results section. Trial registries not searched |
Other bias | High risk | Deviation from protocol was reported by authors Some contamination was reported by the authors and this would have reduced the difference between the 3 groups |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Blinding was not possible |
Blinding of outcome assessment (detection bias) All outcomes | High risk | The DIS was not blinded, DIS did the interview before randomisation and also the intervention. No blinding of data entry personnel or data analyst No control in place to ensure 2‐day waiting period |