Nuotto 1983.

Methods	3 placebo‐controlled randomised trials comparing the psycho‐physiological effects of scopolamine and ephedrine in the prevention of motion sickness
Participants	58 young, healthy male volunteers
Interventions	Study 1: intravenous scopolamine (7.6 mg/kg) or intravenous placebo (0.9% Nacl) Studies 2 and 3: oral doses of scopolamine hydrobromide (0.3 mg, 0.9 mg) ephedrine (25 mg), combined scopolamine hydrobromide and ephedrine (0.3 mg + 25 mg; 0.9 mg + 25 mg) or placebo (lactose)
Outcomes	A. Objective measurements of psycho‐physiological effects of treatment measured by the following tests: co‐ordination, reactive skills, tapping speed, hand co‐operation, speed anticipation, body sway, flicker fusion, eso‐ and exophoria, nystagmus, near point of vision and pupil diameter, memory and learning tasks, digit symbol substitution, Burdon Wiersma, blood pressure and heart rate B. Subjective assessments of current state using visual analogue rating scales
Notes	Schulz rating: randomisation B; allocation concealment A; selection bias B; blinding A
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate