| Methods |
Randomised, double‐blind trial comparing scopolamine with cinnarizine in the prevention and treatment of seasickness |
| Participants |
179 healthy male volunteer personnel with a history of seasickness serving on 2 warships |
| Interventions |
Prophylactic treatment of seasickness with gelatin capsules containing either scopolamine (or cinnarizine). Treatment was dispensed 4 hours prior to nauseogenic ship motion and continued at 6‐hour intervals. Dosage information was not provided. |
| Outcomes |
6‐hour intervals of subjective scores for a range of symptoms including: seasickness, headache, stomach awareness, drowsiness, dry mouth, visual disturbance, performance impairment and number of vomiting events |
| Notes |
Schulz rating: randomisation B; allocation concealment B; selection bias B; blinding A |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
