Uijdehaage 1993.

Methods	Randomised controlled trial comparing scopolamine with methscopolamine and placebo for physiological parameter measurements and prevention of motion sickness symptoms
Participants	60 male college students (mean age 19.7 years) who were susceptible to vection‐induced motion sickness. Individuals with a history of neurological, cardiovascular or gastrointestinal disorders were not eligible.
Interventions	Solution of either scopolamine (0.6 mg), meth‐scopolamine (2.5 mg) or placebo solution in 100 ml of water taken approximately 1 hour prior to vection‐induced motion sickness
Outcomes	Physiological measurements taken immediately after ingestion of treatment, after 1 hour and whilst participant is seated in drum both whilst stationary and in rotation. Subjective motion sickness scores taken every 2 minutes whilst in motion.
Notes	Subjects were requested to not use any medication, alcohol or drugs 24 hours before testing, not to drink caffeine‐containing beverages 12 hours prior and to refrain from smoking, heavy exercise and eating 4 hours prior to testing Schulz rating: randomisation B; allocation concealment B; selection bias B; blinding A
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear