van Marion 1985.

Methods	Randomised controlled trial comparing the protective effect of transdermal scopolamine with transdermal placebo against motion sickness during a 7‐day sea voyage
Participants	49 health sailors aged 17 to 45 years with a previous history of motion sickness
Interventions	Transdermal scopolamine (developed to release 0.5 mg constantly over 72 hours) or transdermal placebo applied 4 hours prior to departure on a 7‐day sea voyage. Patches were removed after 72 hours.
Outcomes	Subjective record of motion sickness symptoms (cold sweating, pallor, nausea and vomiting), drowsiness and ability to perform tasks on a visual analogue scale on days 1, 2, 3, 4 and 6 Subjective reporting of side effects Objective physiological measurements recorded on days 1, 4 and 6 Performance on an information processing task the day prior to departure and on day 1
Notes	No restraints in washing or bathing were imposed. Subjects received 50 mg cyclizine tablets as supplemental medication on request Schulz rating: randomisation B; allocation concealment B; selection bias B; blinding A
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear