| Study | Reason for exclusion |
|---|---|
| Abu Raya 2014 | Not a trial. Serological outcomes only: antibody titre against tetanus and diphtheria in paired maternal cord sera. |
| Abuwa 1997 | Not a trial. |
| Al‐Safi 2011 | Narrative review. |
| Anh 1999 | Not a trial. Serological measurement with means of the Toxin Binding Inhibition Test on pregnant women and children after 2 doses TT. |
| Axelsson 2002 | Review on umbilical cord care and prevention of infections. |
| Aylward 1996 | Surveillance study. |
| Baltazar 1994 | Case‐control study on efficacy of prenatal TT immunisation in preventing neonatal tetanus. |
| Basher 2010 | Cross‐sectional study assessing vaccination coverage and educational status in a sample of undergraduate female students in Bangladesh. |
| Berggren 1971 | Retrospective survey. |
| Blencowe 2010 | Systematic review. |
| Canning 2011 | Follow‐up study assessing schooling attainment on babies born from mothers who were immunised several years earlier (Black 1980). |
| Chai 2004 | Case‐control study. |
| Chongsuvivatwong 1993 | Incidence of neonatal tetanus mortality before and after mass immunisation in Thailand. |
| de Walque 2008 | Not comparative. |
| Dhillon 1975 | Not a trial. Only serological outcomes. |
| Dietz 1996 | Review. |
| Erener‐Ercan 2014 | Not a trial. Serological outcomes only: antibody titre against tetanus and diphtheria in paired maternal cord sera. |
| Gupta 1998 | Cohort study. |
| Halperin 2011 | Interventions (vaccine or placebo) were administered after delivery (post‐partum study) |
| Hardy‐Fairbanks 2013 | Not a trial (cohort study). Antibody titre in maternal, cord blood and infant. |
| Hasnain 2007 | Survey assessing the reasons for low vaccination coverage. |
| Heredia 1968 | Not a trial. Only serological assessment. |
| Hlady 1992 | Case‐control study. |
| Hurmez 2012 | Not a comparative study. Seroprevalence and TT vaccine coverage assessed on a sample of 600 pregnant women in Iraq. |
| Juan‐Giner 2014 | Trial assessing antibody response to 2 TT vaccines that underwent either controlled temperature chain or standard cold chain in women between 14 and 49 years. |
| Kielmann 1977 | Not a trial. Administration of TT with 2 different adjuvants in women of reproductive age. Only serological outcomes. |
| Koenig 1998 | Not a trial. 10‐year follow‐up conducted on half of the area where Black 1980 was carried out. |
| Krishnan 2013 | Study assessing whether differential excess mortality among Indian girl children could be associated with vaccinations (GBS, DTP, measles). |
| Lassi 2010 | Cochrane review about efficacy of community‐based intervention packages to prevent neonatal tetanus. Vaccination is not included. |
| MacLennan 1965 | No intervention: administration of vaccines containing same toxoids but different adjuvants in women of reproductive age. Efficacy outcomes are only serological. |
| Mulholland 1996 | No intervention: trial with polyribosylribitol phosphate‐tetanus vaccine. |
| Nohynek 1999 | No intervention: participants were children receiving conjugate Hib and DTP vaccine, who were born from mother immunised with different doses of TT (0, 1, 2, 3 and more). |
| Orozova‐Bekkevold 2007 | Not about tetanus immunisation. |
| Perry 1998 | Report on TT immunisation coverage. |
| Rahman 1982b | Consensus to vaccination. |
| Rahman 1982a | Not a trial. Vaccination of pregnant women with 3 doses of TT. Immunisation program conducted in half of the Matlab area after Black 1980. |
| Relyveld 1991 | Only serological outcomes. |
| Salama 2009 | Efficacy outcome is not of interest: immune response to vaccination assessed in women after immunisation. |
| Schofield 1961 | Not a trial. |
| Shakib 2013 | Cohort study. |
| Silveira 1995 | Case‐control to assess relationship between exposition to TT in pregnancy and malformation in the newborns. |
| Stanfield 1973 | Not a trial. Variation of seral antitoxin after administration of different TT preparation to pregnant women. |
| Suri 1964 | Not a trial. Different TT preparations were administered and antitoxins in cord blood were measured. |
| Tall 1991 | Case‐control study. |
| Traverso 1991 | Case‐control study for assessing risk of developing neonatal tetanus, TT immunisation of the mothers was not evaluated as associated factor. |
| Yala 1980 | Not a trial. |
| Yusuf 1991 | Follow‐up survey to determine incidence of neonatal tetanus before and after a vaccination campaign in Indonesia. |
DTP: diphtheria, tetanus and pertussis GBS: group B streptococcus Hib: H. Influenza TT: tetanus toxoid