Hou 2004.

Methods	Data collection: 01/2001 to 02/2003. Exclusion from analysis: positive initial bacteriological sample. Follow‐up period: until death or 3 months.
Participants	Taiwan Hospitalised patients with endoscopy‐proven gastroesophageal variceal bleeding without signs of infection. Etiology of bleeding: endoscopy‐proven gastroesophageal variceal bleeding. Endoscopic procedure was completed within 24 h of admission or bleeding onset. Endoscopic variceal ligation or sclerotherapy was preceded by vasoactive agent or balloon tamponade. Child‐Pugh class (A/B/C): 20/64/27.
Interventions	Experimental: intravenous ofloxacin 200 mg b.i.d. for 2 days followed by oral ofloxacin 200 mg b.i.d. for 5 days. Control: no antibiotic prophylaxis.
Outcomes	Rebleeding rate.
Notes	The authors were contacted via e‐mail and no response was received (23‐June‐2010).
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	The sequence was generated using a random number software.
Allocation concealment?	Unclear risk	No information provided.
Blinding? All outcomes	High risk	Not a blinded trial.
Incomplete outcome data addressed? All outcomes	Low risk	Missing data are balanced in number across the intervention groups.
Free of selective reporting?	Low risk	The report include all the expected outcomes.
Free of other bias?	Low risk	The trial appears to be free of other sources of bias.
Intention to treat analysis?	High risk	The exclusion of the patients was not based on an exclusion rule.
Sample calculation?	Low risk	The sample was calculated considering the expected rebleeding rate.