Soriano 1992.

Methods	Data collection: 08/89 to 06/91. Exclusion from analysis: underwent surgery, or died within 24 hs after admission. Follow‐up period: up to four weeks.
Participants	Spain Hospitalised cirrhotic patients with upper gastrointestinal haemorrhage, without infection or treatment with antibiotics in the previous two weeks. Etiology of bleeding: oesophageal varices, gastric haemorrhage, peptic ulcers, and others. Initial infection assessment: chest X‐ray, white blood cell count, urine/blood/ascites culture. Source of bleeding determined by endoscopy scheduled within four hs after enrolment. Emergency sclerotherapy performed for patients bleeding from varices. Child‐Pugh class A/B/C: 40/55/24.
Interventions	Experimental: oral norfloxacin 800 mg/day during seven days. Control: no antibiotic prophylaxis.
Outcomes	Prevent bacterial infection.
Notes	Authors were contacted for the first version of this review.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	The sequence was generated using a table of random numbers.
Allocation concealment?	Unclear risk	No information provided.
Blinding? All outcomes	High risk	Not a blinded trial.
Incomplete outcome data addressed? All outcomes	Low risk	Reassons for missing data are based on the violation of the protocol and are balanced across the groups.
Free of selective reporting?	Low risk	The report include all the expected outcomes.
Free of other bias?	Low risk	The trial appears to be free of other sources of bias.
Intention to treat analysis?	High risk	The exclusion of the patients was based on an exclusion rule.
Sample calculation?	High risk	No sample calculation procedure.