| Methods |
Randomized controlled clinical trial |
| Participants |
One hundred and fifteen patients undergoing pulmonary resections including pneumonectomy. One patient was withdrawn because more than one surgical procedure was required. Fifty‐five were assigned to the fibrin glue group and 59 to the control group. Seventy‐seven patients were male and 37 female; their mean age was 59 years |
| Interventions |
A) Intervention group: standard surgical treatment; fibrin glue was applied to bronchial stumps and lung surfaces. B) Control group: standard surgical treatment with no additional fibrin glue |
| Outcomes |
Primary: difference in air‐tolerance‐pressure before and after fibrin glueing; rate of patients with postoperative bronchopleural or pulmonary leakages; number of days with persistent air leakage, only for patients who presented an air leak on the first postoperative day. Secondary: length of stay in the intensive care unit; length of hospital stay; duration of intubation after surgery; number of days with chest tubes; rate of complications; daily amount of secretion from chest tubes; general condition of the patient |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Patients were randomized by a close‐envelope system |
| Allocation concealment? |
Low risk |
Closed envelopes were sequentially opened after pulmonary resection |
| Blinding?
All outcomes |
Unclear risk |
Insufficient information about this item |
| Incomplete outcome data addressed?
All outcomes |
Low risk |
No missing outcome data |
