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. 2010 May 28;375(9729):1896–1905. doi: 10.1016/S0140-6736(10)60357-1

Table 2.

Macaques given four (study 1) or seven treatments (study 2) with stable nucleic acid-lipid particles containing Zaire Ebola virus (ZEBOV) small interfering RNAs (siRNAs) after ZEBOV challenge

Adverse events on days 1–35 after ZEBOV challenge Status
Study 1
Animal 1 Anorexia (days 7–9), lymphopenia (day 6), >5-fold increase in AST (day 10) Survived
Animal 2 Fever (day 6), mild rash (days 8,11, and 12), moderate rash (days 9 and 10), depression (days 7–11), anorexia (days 7–11), diarrhoea (day 12), lymphopenia (days 6 and 14), thrombocytopenia (day 6), 2–3-fold increase in ALP (day 10), 2–3-fold increase in ALT (day 10), 2–3-fold increase in AST (day 6), >5-fold increase in AST (day 10), >5-fold increase in GGT (day 10) Survived
Animal 3 Mild rash (days 6–10), depression (days 6–-10), anorexia (days 6–10), bleeding at venepuncture site (day 10), recumbency (day 10), thrombocytopenia (day 6), 2–3-fold increase in ALP (day 6), >5-fold increase in ALP (day 10), 4–5-fold increase in ALT (day 10), 2–3-fold increase in AST (day 3), >5-fold increase in AST (days 6 and 10), >5-fold increase in BUN (day 10), >5-fold increase in creatinine (day 10), >5-fold increase in GGT (day 10) Died on day 10
Control 1* Mild rash, anorexia, and depression on day 5 Died day 6
Study 2
Animal 4 Thrombocytopenia (days 6 and 10), 4–5-fold increase in AST (day 6) Survived
Animal 5 >5-fold increase in AST (day 6), 2–3-fold increase in AST (day 10) Survived
Animal 6 Fever (day 10), lymphopenia (day 6), thrombocytopenia (days 6, 10, and 14), 2–3-fold increase in AST (day 10) Survived
Animal 7 Fever (day 10), lymphopenia (day 6), thrombocytopenia (day 6), >5-fold increase in AST (day 10) Survived
Control 2 Fever (day 6), moderate rash (day 10), recumbency (day 10), thrombocytopenia (day 6) 2–3-fold increase in ALT (day 6), >5-fold increase in ALT (day 10), >5-fold increase in AST (days 6 and 10), >5-fold increase in BUN (day 10), 2–3-fold increase in creatinine (day 10) Died on day 10

Fever was defined as a temperature that was 2·5° greater than baseline temperature or at least 1·5° greater than baseline temperature, and at least 103·5°F. Mild rash was defined as focal petechiae covering less than 10% of skin. Moderate rash was defined as petechiae covering between 10% and 40% of skin. Severe rash was defined as petechiae or ecchymoses covering more than 40% of skin. Lymphopenia was defined as at least a 35% reduction in numbers of lymphocytes; and thrombocytopenia was defined as at least a 35% reduction in numbers of platelets. AST=aspartate aminotransferase. ALP=alkaline phosphatase. ALT=alanine aminotransferase. GGT=γ glutamyltransferase. BUN=blood urea nitrogen.

*

Not given any siRNAs.

Given seven treatments with non-specific siRNAs.