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. 2020 Mar 31;11:522. doi: 10.3389/fimmu.2020.00522

Figure 1.

Figure 1

The vicious cycle leading to bronchiectasis in the setting of a primary antibody deficiency. While the host defect of the immune system impairs the response to pulmonary infections, the defect also directly causes immune dysregulation and a chronic inflammatory state in many patients. Many factors, including secondarily impaired mucociliary clearance, contribute to the process of progressive lung damage.