Table 1. Potential cellular origin of hepatic myofibroblasts.
Potential Cell Types | Potential Biomarkers | References |
---|---|---|
Hepatic stellate cells (HSCs) |
• GFAP • Desmin • LRAT • PDGFRβ • HAND2 |
[17, 18] |
Portal fibroblasts (PFs) |
• Elastin • Thy-1 • NTPDase2 |
[15, 24] |
Hepatocytes |
• FSP-1 • FAP |
[28, 32] |
Hepatic progenitor cell (HPCs) |
• CD133 • CK-7 |
[34, 35] |
Fibrocytes |
• CD11b, CD34, CD45, CD54, CD80, CD86, CCR1, CCR2, CCR5, CCR7, MHCII, Gr1, Ly6c • Collagen type 1, Fibronectin, Vimentin |
[36, 38] |
Mesothelial cells (MCs) |
• GPM6 • ITGA8 |
[45, 46] |
Abbreviations: GFAP: glial fibrillary acidic protein. LRAT: lecithin retinol acyltransferase. PDGFRβ: platelet-derived growth factor receptor-β. HAND2: heart- and neural crest derivatives-expressed protein 2. NTPDase2: Ectonucleoside Triphosphate Diphosphohydrolase 2. FSP-1: fibroblast specific protein-1. FAP: Fibroblast Activation Protein Alpha. CK-7: Type II Cytoskeletal 7. MHC II: Major Histocompatibility Complex, Class II. GPM6: Glycoprotein M6. ITGA8: integrin α8.