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. 2020 Mar 31;11(13):1186–1201. doi: 10.18632/oncotarget.27532

Table 1. Potential cellular origin of hepatic myofibroblasts.

Potential Cell Types Potential Biomarkers References
Hepatic stellate cells (HSCs)

• GFAP

• Desmin

• LRAT

• PDGFRβ

• HAND2

[17, 18]
Portal fibroblasts (PFs)

• Elastin

• Thy-1

• NTPDase2

[15, 24]
Hepatocytes

• FSP-1

• FAP

[28, 32]
Hepatic progenitor cell (HPCs)

• CD133

• CK-7

[34, 35]
Fibrocytes

• CD11b, CD34, CD45, CD54, CD80, CD86, CCR1, CCR2, CCR5, CCR7, MHCII, Gr1, Ly6c

• Collagen type 1, Fibronectin, Vimentin

[36, 38]
Mesothelial cells (MCs)

• GPM6

• ITGA8

[45, 46]

Abbreviations: GFAP: glial fibrillary acidic protein. LRAT: lecithin retinol acyltransferase. PDGFRβ: platelet-derived growth factor receptor-β. HAND2: heart- and neural crest derivatives-expressed protein 2. NTPDase2: Ectonucleoside Triphosphate Diphosphohydrolase 2. FSP-1: fibroblast specific protein-1. FAP: Fibroblast Activation Protein Alpha. CK-7: Type II Cytoskeletal 7. MHC II: Major Histocompatibility Complex, Class II. GPM6: Glycoprotein M6. ITGA8: integrin α8.