Table 5.
ASCT Toxicity With TBC Conditioning Regimen
| Variable | All Patients (n = 48) | PCNSL (n = 27) | SCNSL/CNS Relapse (n = 21) |
|---|---|---|---|
| Interval to neutrophil recovery, d | |||
| Median | 9.5 | 9.0 | 10.0 |
| IQR | 9.0-10.0 | 8.0-10.0 | 9.0-10.0 |
| Interval to platelet recovery, d | |||
| Median | 15.0 | 15.0 | 14.0 |
| IQR | 12.5-19.5 | 14.0-21.0 | 11.0-16.0 |
| Toxicity | |||
| Febrile neutropenia | 43 (89.6) | 25 (52.1) | 18 (37.5) |
| Infection | 32 (66.7) | 18 (37.5) | 14 (29.2) |
| Bacterial | 28 (58.3) | 20 (41.7) | 8 (16.7) |
| Viral | 22 (45.8) | 10 (20.8) | 12 (25.0) |
| Fungal | 4 (8.3) | 3 (6.3) | 1 (2.1) |
| Nausea/vomiting | 41 (85.4) | 22 (45.8) | 19 (39.6) |
| Diarrhea | 45 (93.8) | 26 (54.2) | 19 (39.6) |
| Mucositis | 43 (89.6) | 22 (45.8) | 21 (43.8) |
| Grade 1 or 2 | 26 (54.2) | 12 (25.0) | 14 (29.2) |
| Grade 3 or 4 | 17 (35.4) | 10 (20.8) | 7 (14.6) |
| Dermatologic | 15 (31.3) | 15 (31.3) | 0 (0) |
| Acute neurotoxicity | 13 (27.1) | 10 (20.8) | 3 (6.3) |
| AMS/delirium | 13 (27.1) | 10 (20.8) | 3 (6.3) |
| Seizure | 2 (4.2) | 1 (2.1) | 1 (2.1) |
| Hemorrhagic cystitis | 4 (8.3) | 2 (4.2) | 2 (4.2) |
| Renal injury | 8 (16.7) | 3 (6.3) | 5 (10.4) |
| Electrolyte abnormalities | 43 (89.6) | 24 (50.0) | 19 (39.6) |
| Hypokalemia | 38 (79.2) | 22 (45.8) | 16 (33.3) |
| Hypomagnesemia | 7 (14.6) | 1 (2.1) | 6 (12.5) |
| Hypophosphatemia | 18 (37.5) | 9 (18.8) | 9 (18.8) |
| Hyponatremia | 8 (16.7) | 3 (6.3) | 5 (10.4) |
| Hypernatremia | 6 (12.5) | 4 (8.3) | 2 (4.2) |
| Metabolic alkalosis | 4 (8.3) | 1 (2.1) | 3 (6.3) |
| Metabolic acidosis | 6 (12.5) | 4 (8.3) | 2 (4.2) |
| Cardiac | 8 (16.7) | 5 (10.4) | 3 (6.3) |
| Cardiomyopathy | 1 (2.1) | 0 (0) | 1 (2.1) |
| Arrhythmia | 7 (14.6) | 5 (10.4) | 2 (4.2) |
| Liver function abnormalities | 9 (18.8) | 8 (16.7) | 1 (2.1) |
| Respiratory compromise | 4 (8.3) | 1 (2.1) | 3 (6.3) |
| Transplant-related mortality | 4 (8.3) | 1 (2.1) | 3 (6.3) |
Data presented as n (%).
Abbreviations: AMS = altered mental status; ASCT = autologous stem cell transplantation; CNS = central nervous system; IQR = interquartile range; PCNSL = primary central nervous system lymphoma; SCNSL = secondary central nervous system lymphoma; TBC = thiotepa, busulfan, cyclophosphamide.