1. Meta‐analyses of prevented fractions: D(M)FS and D(M)FT.

Analysis	Number of studies	RE estimate	95% CI	Meta‐analysis P‐values	Heterogeneity test
D(M)FS ‐ all studies	25	28%	(19% to 36%)	P < 0.0001	Chi2 = 136 (24 df); P < 0.0001; I² = 82%
D(M)FS ‐ placebo control	15	21%	(15% to 28%)	P < 0.0001	Chi2 = 23 (14 df); P = 0.07; I² = 38%
D(M)FS ‐ no‐treatment control	10	38%	(24% to 52%)	P < 0.0001	Chi2 = 63 (9 df); P < 0.0001; I² = 86%
D(M)FT ‐ all studies	10	32%	(19% to 46%)	P < 0.0001	Chi2 = 103 (9 df); P < 0.0001; I² = 91%
D(M)FT ‐ placebo control	4	18%	(9% to 27%)	P < 0.0001	Chi2 = 3.2 (3 df); P = 0.37; I² = 6%
D(M)FT ‐ no‐treatment control	6	43%	(29% to 57%)	P < 0.0001	Chi2 = 48 (5 df); P < 0.0001; I² = 90%

CI = confidence interval
D(M)FS/T = decayed, (missing) and filled permanent surfaces or teeth
df = degrees of freedom
RE = random effects