Comparison 1. Any pharmacological treatment versus Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Discontinuation rates	4	125	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.29, 0.94]
1.1 Amineptine	2	74	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.07, 0.69]
1.2 Mirtazapine	2	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.49, 1.97]
2 Average score in global state	3	103	Mean Difference (IV, Fixed, 95% CI)	‐0.27 [‐0.54, ‐0.01]
2.1 Amineptine	2	72	Mean Difference (IV, Fixed, 95% CI)	‐0.49 [‐0.80, ‐0.17]
2.2 Mirtazapine	1	31	Mean Difference (IV, Fixed, 95% CI)	0.30 [‐0.22, 0.82]
3 Average score in withdrawal symptoms	2	74	Std. Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.54, 0.38]
3.1 Amineptine	1	43	Std. Mean Difference (IV, Random, 95% CI)	‐0.26 [‐0.86, 0.34]
3.2 Mirtazapine	1	31	Std. Mean Difference (IV, Random, 95% CI)	0.17 [‐0.54, 0.89]
4 Average score in craving	1	29	Mean Difference (IV, Fixed, 95% CI)	0.43 [‐1.23, 2.09]