Morel 1984.
Methods | Randomised but not blind Disease control = number new blisters between days 21 to 51 Follow‐up: 51 days ( = treatment period) |
|
Participants | 50 participants with BP confirmed by IF studies. | |
Interventions | A: 24/26 prednisolone 0.75 mg/kg/day. B: 22/24 prednisolone 1.25 mg/kg/day. |
|
Outcomes |
|
|
Notes | 2 dropouts in each group, no reasons given, and not included in analysis Erythromycin used for infection but its anti‐inflammatory effect not evaluated or commented upon |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "using a single table of pre‐established and balanced randomisation for all 8 patients." (Translation, page 926). |
Allocation concealment (selection bias) | Unclear risk | No details given. |
Blinding (performance bias and detection bias) All outcomes | High risk | No. No details given. |
Incomplete outcome data (attrition bias) All outcomes | High risk | 2 dropouts in each group, no reasons given, and not included in analysis. |
Selective reporting (reporting bias) | Low risk | New blister formation at days 21 and 51 reported. |
Other bias | Unclear risk | Some participants that could have been recruited were excluded on the grounds that they were able to take part in a parallel study involving plasma exchanges. |