Comparison 1. Main analysis for cisapride versus no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 'Worse, same or slight improvement' versus 'moderate or excellent improvement'	7	236	Odds Ratio (M‐H, Random, 95% CI)	0.34 [0.10, 1.19]
2 Mean daily regurgitations	1	12	Mean Difference (IV, Fixed, 95% CI)	‐0.90 [‐4.10, 2.30]
3 Mean daily weight gain	1	12	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐7.65, 7.05]
4 Reflux index	5	176	Mean Difference (IV, Random, 95% CI)	‐6.49 [‐10.13, ‐2.85]
5 Adverse events	4	190	Odds Ratio (M‐H, Random, 95% CI)	1.86 [0.88, 3.93]