Table II.

Changes in water consumption in rats ml/(kg/day).

Group	Time interval, weeks
	1	2	3	4	5	6	7	8
E36eu	132.24±2.24D	136.0±2.07a	151.44±3.00a,B,c	144.29±7.28a	152.56±9.45	154.40±3.50A,d	143.05±2.39a,c,D	148.23±1.62A,d
E36e	142.21±2.06c	140.03±2.05A,c	141.92±9.02a	160.22±11.66A	155.75±2.59a	161.93±1.37A,B	153.60±2.59a,c	156.25±1.93
E	136.48±2.24	145.04±2.64A	144.48±1.01a	142.66±2.02a,b	154.28±6.23	157.70±1.56A	147.87±1.57a	142.00±2.96
NS	136.10±1.98	136.70±1.94a	141.06±2.41a	135.90±2.04a	153.56±0.54a	150.17±2.16a	157.43±7.79A	147.86±1.72
Con	119.08±1.11	110.99±3.27	113.81±4.14	115.96±3.10	118.33±6.17	118.46±1.69	117.70±5.85	121.81±3.22

^aP<0.05 and

^AP<0.01 vs. Con group.

^bP<0.05 and

^BP<0.01 vs. NS group.

^cP<0.05 vs. E group.

^dP<0.05 and

^DP<0.01 vs. E36e group.

E36eu, recombinant uricase-expressing genetically engineered E. coli bacteria group; E36e, empty vector-expressing engineered E. coli bacteria group; E, E. coli group; NS, carboxymethylcellulose suspension group; Con, blank control.