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. 2020 Feb 20;45(5):1275–1293. doi: 10.3892/ijmm.2020.4507

Figure 2.

Figure 2

Current understanding of the effect of TSP-1 and TSP-2 on various CVDs. The red arrows represent suppression, the green arrows represent promotion and the blue arrows represent not acquired. The primary roles TSP-1 and TSP-2 serve in CVDs are considered to be inhibitory, but there are different hypotheses regarding the contribution of TSP-1 and TSP-2 to certain CVDs, including atherosclerosis and arterial restenosis. However, the association between TSP-1 and TSP-2 and diseases such as valvular disease requires further study. TSP, thrombospondin; CVD, cardiovascular disease.