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. 2020 Feb 28;45(5):1305–1316. doi: 10.3892/ijmm.2020.4520

Figure 5.

Figure 5

Effects of geniposide inflammatory cytokine levels in the presence or absence of miR-21 M or miR-21 I in ox-LDL-treated HUVECs. HUVECs were transfected with miR-21 mimic M, miR-21 I or miR-NC and then treated with geniposide (40 μM) for 1 h prior to ox-LDL (50 μg/ml) treatment for 24 h. The levels of (A) IL-1β, (B) IL-6, (C) TNF-α and (D) IL-10 in the culture supernatant were detected by enzyme-linked immunosorbent assay kits. Data are shown as means ± standard deviation, n=3. **P<0.01 vs. control group. #P<0.05, ##P<0.01 vs. ox-LDL treatment group; &P<0.05, &&P<0.01 vs. ox-LDL + GEN + miR-NC co-treatment group. GEN, geniposide; ox-LDL, oxidized low-density lipoprotein; miR-21 M, miR-21 mimic; miR-21 I, miR-21 inhibitor; miR-NC, miRNA negative control; NS, no significance.