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. 2020 Feb 26;45(5):1447–1463. doi: 10.3892/ijmm.2020.4515

Figure 7.

Figure 7

Inhibitor downregulates BDNF expression and damages the morphology of cortical neurons in the ischemic penumbra after middle cerebral artery occlusion. (A) Protein expression levels and western blot analysis of BDNF. Data are presented as the mean ± SD (n=3). (B) Immunofluorescence of BDNF-positive cells in the ischemic penumbra. Scale bars=20 μm. (C) The number of BDNF-positive cells in the ischemic penumbra. Data are presented as the mean ± SD (n=6). (D) Transmission electron microscopy showed the neuron nucleus structures (n=3). Scale bars=0.5 μm. ##P<0.01 vs. the M7 group; ▲▲P<0.01 vs. the M14 group. M group, model group; SD, standard deviation; BDNF, brain derived neurotrophic factor; DAPI, 4,6-diamidino-2-phenylindole.