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. 2020 Feb 26;45(5):1447–1463. doi: 10.3892/ijmm.2020.4515

Figure 9.

Figure 9

Inhibition of the Wnt/β-catenin signaling pathway suppresses exercise-promoted neurogenesis in the ischemic penumbra. (A) Protein expression levels and western blot analysis of Wnt3a. (B) Protein expression levels and western blot analysis of nucleus β-catenin. Data are presented as the mean ± SD (n=3). (C) IF of Nestin/BrdU-positive cells in the ischemic penumbra. (D) IF of Dcx/BrdU-positive cells in the ischemic penumbra. (E) The number of Nestin/ BrdU-positive cells in the ischemic penumbra. (F) The number of Dcx/BrdU-positive cells in the ischemic penumbra. Data are presented as the mean ± SD (n=6). Scale bars=20 μm. $$P<0.01 vs. the EM7 group; &P<0.05 and &&P<0.01 vs. the EM14 group. EM group, treadmill training model group; IF, immunofluorescence; BrdU, bromodeoxyuridine.