Figure 3.

Virulence of KST0555 in a mouse colitis model. Survival curve of BALB/c mice (n=5) were pretreated with 20 mg streptomycin, followed by inoculation orally with 1×10⁷, 5×10⁷ and 1×10⁸ CFU KST0555 and 1×10⁷ CFU WT. (A) Mice survival and (B) body weight change was monitored for 21 days. Mice organs were dissected at the time of mortality or 72 hpi. The number of bacteria in the (C) cecum, (D) mLN, (E) spleen and (F) blood were counted. Data were presented as the mean ± standard deviation. ^*P<0.05, ^**P<0.05 and ^***P<0.001 vs. WT. CFU, colony forming unit; WT, wild type; hpi, hours post-infection; mLN, mesenteric lymph nodes.