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. 2020 Feb 18;45(5):1327–1340. doi: 10.3892/ijmm.2020.4505

Figure 6.

Figure 6

Protection by the adopted transfer of KST0555-vaccinated mice serum and CD8+ T cells against Salmonella infection. (A) Serum (300 μl) from PBS or KST0555-immunized mice was inoculated intraperitoneally into naïve BALB/c mice (n=5). At 12 h following inoculation, mice were challenged orally with 107 CFU of WT. Mouse survival was monitored for 14 days. Mice were immunized with KST0555 three times at 14-day intervals orally, and the spleen was dissected from the mice 7 days following final immunization. (B) Splenic CD4+ T cells or (C) CD8+ T cells from PBS- or KST0555-immunized mice were transferred intraperitoneally to naïve BALB/c mice (n=5). At 12 h following inoculation, mice were challenged orally with 107 CFU of WT, and mouse survival was monitored for 14 days. **P<0.05 and ***P<0.001 vs. the PBS group. PBS, phosphate buffered saline; CFU, colony-forming units; WT, wild-type.