Table 2. Sensitivity (sens), specificity (spec), area under the curve (AUC), positive predictive value (PPV), and negative predictive value (NPV) of screening methods for harmful alcohol use and alcohol dependence symptoms and consequences among gender minority participants of The PRIDE study (N = 1892).
| Screening method | All gender minority people | Gender-expansive | Transfeminine | Transmasculine | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sens (%) | Spec (%) | AUC (95% CI) | PPV (%) | NPV (%) | Sens (%) | Spec (%) | AUC (95% CI) | PPV (%) | NPV (%) | Sens (%) | Spec (%) | AUC (95% CI) | PPV (%) | NPV (%) | Sens (%) | Spec (%) | AUC (95% CI) | PPV (%) | NPV (%) | |
| Harmful alcohol use* | ||||||||||||||||||||
| 4 drinks/occasion | 98.77 | 59.25 | 0.79 (0.77–0.80) | 26.32 | 99.69 | 98.22 | 58.13 | 0.78 (0.76–0.80) | 27.04 | 99.52 | 100.00 | 62.87 | 0.81 (0.78–0.85) | 28.57 | 100.00 | 100.00 | 60.48 | 0.80 (0.78–0.83) | 22.80 | 100.00 |
| 5 drinks/occasion | 97.12 | 68.77 | 0.83 (0.81–0.84) | 31.42 | 99.39 | 96.45 | 68.13 | 0.82 (0.80–0.84) | 32.34 | 99.18 | 100.00 | 72.77 | 0.86 (0.83–0.89) | 35.29 | 100.00 | 97.73 | 68.44 | 0.83 (0.80–0.86) | 26.54 | 99.61 |
| Alcohol dependence symptoms & consequences† | ||||||||||||||||||||
| 4 drinks/occasion | 86.37 | 69.91 | 0.78 (0.76–0.80) | 57.68 | 91.53 | 85.99 | 69.19 | 0.78 (0.75–0.80) | 58.96 | 90.56 | 89.06 | 71.43 | 0.80 (0.75–0.85) | 54.29 | 94.49 | 86.29 | 71.04 | 0.79 (0.75–0.83) | 55.44 | 92.54 |
| 5 drinks/occasion | 76.68 | 77.86 | 0.77 (0.75–0.79) | 62.18 | 87.55 | 76.48 | 77.75 | 0.77 (0.75–0.80) | 63.89 | 86.53 | 82.81 | 80.95 | 0.82 (0.76–0.87) | 62.35 | 92.52 | 74.19 | 76.43 | 0.75 (0.71–0.80) | 56.79 | 87.64 |
| AUDIT1: Frequency of drinking | 83.42 | 64.30 | 0.74 (0.72–0.76) | 52.59 | 89.09 | 82.42 | 63.57 | 0.73 (0.71–0.75) | 53.80 | 87.54 | 85.94 | 61.90 | 0.74 (0.68–0.80) | 46.22 | 92.04 | 85.48 | 67.68 | 0.77 (0.72–0.81) | 52.48 | 91.78 |
| AUDIT2: Number of drinks on a typical day | 42.36 | 91.50 | 0.67 (0.65–0.69) | 70.30 | 76.98 | 40.86 | 92.30 | 0.67 (0.64–0.69) | 73.19 | 75.20 | 45.31 | 89.29 | 0.67 (0.61–0.74) | 61.70 | 81.08 | 45.97 | 90.57 | 0.68 (0.64–0.73) | 67.06 | 80.06 |
| AUDIT-C, cutoff score 3 or more | 75.53 | 78.18 | 0.77 (0.75–0.79) | 62.16 | 87.07 | 75.06 | 79.58 | 0.77 (0.75–0.80) | 65.42 | 86.11 | 82.81 | 74.40 | 0.79 (0.73–0.84) | 55.21 | 91.91 | 73.39 | 76.43 | 0.75 (0.70–0.80) | 56.52 | 87.31 |
| AUDIT-C, cutoff score 4 or more | 51.72 | 90.72 | 0.71 (0.69–0.73) | 72.58 | 79.84 | 50.36 | 90.95 | 0.71 (0.68–0.73) | 74.13 | 78.07 | 57.81 | 89.88 | 0.74 (0.67–0.80) | 68.52 | 84.83 | 53.23 | 90.57 | 0.72 (0.67–0.77) | 70.21 | 82.26 |
*Harmful alcohol use was measured on the AUDIT using a cut point of ≥8
†Alcohol dependence symptoms and consequences were the endorsement of ≥ 1 experiences or symptoms on the AUDIT items 4–9