Table 1. Demographic and clinical characteristics of children with laboratory-confirmed drug-resistant TB in three provinces of south Africa 2008–2010 by record of treatment at designated treatment facilities (N = 156).
| Total (N = 156) n (%) | No Record of Treatment (n = 87) n(%) | Record of Treatment (n = 69) n(%) | P-value | |
|---|---|---|---|---|
| Age (Median, IQR)* | 6 [0–10] | 2 [0–9] | 9 [5–11] | p<0.001 |
| Gender† | n = 150 | n = 83 | n = 67 | p = 0.68 |
| Female | 80 (53) | 43 (52) | 37 (55) | |
| Male | 70 (47) | 40 (48) | 30 (45) | |
| Province‡ | p = 0.24 | |||
| Eastern Cape | 68 (44) | 40 (46) | 28 (41) | |
| Gauteng | 78 (50) | 44 (51) | 34 (49) | |
| Limpopo | 10 (6) | 3 (3) | 7 (10) | |
| Level of Diagnosing Facility‡ | ||||
| Tertiary Care | 18 (12) | 1 (1) | 17 (25) | Reference |
| General Hospital | 97 (62) | 60 (69) | 37 (54) | P<0.001 |
| Health Clinic | 36 (23) | 23 (26) | 13 (19) | P<0.001 |
| Community Health Center | 5 (3) | 3 (3) | 2 (3) | p = 0.13 |
| Diagnostic Specimen Type† | ||||
| Sputum | 99 (64) | 46 (53) | 53 (78) | Reference |
| Aspirate | 22 (14) | 14 (16) | 8 (12) | p = 0.67 |
| Extrapulmonary Specimen | 34 (22) | 27 (31) | 7 (10) | p = 0.01 |
| Drug Susceptibility Test Type† | ||||
| LPA Only | 26 (17) | 20 (23) | 6 (9) | Reference |
| MGIT Only | 83 (53) | 41 (47) | 42 (61) | p = 0.08 |
| LPA + MGIT | 47 (30) | 26 (30) | 21 (30) | p = 0.34 |
| Drug Resistance Category‡ | ||||
| Multidrug Resistance | 149 (96) | 86 (99) | 63 (91) | Reference |
| Monodrug Resistance | 4 (3) | 0 (0) | 4 (6) | p = 0.10 |
| Extensive Drug-Resistance | 3 (2) | 1 (1) | 2 (3) | p = 1 |
*Wilcox-Mann-Whitney test for significance for Age
†Pearson’s Chi-sq test for significance for Gender, Drug Susceptibility Test Type, Specimen Type (pairwise comparisons adjusted with Bonferroni method)
‡Fisher’s Exact Test for significance for Province, Level of Diagnosing Facility, and Drug Resistance Category (pairwise comparisons adjusted using Bonferroni method)