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. 2020 Jan 29;14(4):896–913. doi: 10.1002/1878-0261.12639

Figure 1.

Figure 1

Identification of HCC subclasses using NMF consensus clustering in the metadata set. (A) Flow chart of the study. (B) NMF clustering using 816 metabolism‐associated genes. Cophenetic correlation coefficient for k = 2–5 is shown. (C) t‐SNE analysis supported the stratification into three HCC subclasses. (D). OS and RFS of three subclasses (C1, C2, and C3) in metadata set, independent TCGA or ICGC cohort, and http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14520 cohort. The statistical significance of differences was determined by log‐rank test.