Table 1.

IC₅₀ in PKC412‐ and sorafenib‐sensitive and PKC412‐ and sorafenib‐resistant cell lines. 1 × 10⁴ cells were cultured with increasing concentration of PKC412 (5–1000 nm). Cell viability was measured after addition of MTS. The respective IC₅₀ was calculated by nonlinear regression analysis (log inhibitor vs. response). Mean IC₅₀ (n = 6; 2 experiments) with standard error (SE) as LogIC₅₀ is depicted

PKC412			Sorafenib
Cell line	IC50 in nmol/l	SEM as LogIC50	Cell line	IC50 in nmol/l	SEM as LogIC50
MOLM13	32.17	0.05	MOLM13	4.66	0.05
PKC C5	105.0	0.03	Sora C4	267	0.04
PKC E9	136.2	0.03	Sora D3	291	0.12
PKC F6	147.0	0.07	Sora D11	63.9	0.16
PKC F9	156.1	0.02	Sora E7	264	0.15
PKC G7	170.5	0.08	Sora G8	68.1	0.10