Comparison 2. Subgroup: Mitomycin C dacryocystorhinostomy versus dacryocystorhinostomy alone.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Functional success, defined as the relief of epiphora at 6 months	7	356	Risk Ratio (IV, Random, 95% CI)	1.12 [0.98, 1.29]
1.1 EN‐DCR	3	144	Risk Ratio (IV, Random, 95% CI)	1.17 [0.88, 1.56]
1.2 EX‐DCR	4	212	Risk Ratio (IV, Random, 95% CI)	1.10 [0.94, 1.29]
2 Functional success, defined as the relief of epiphora at > 6 months	14	909	Risk Ratio (IV, Random, 95% CI)	1.15 [1.07, 1.25]
2.1 EN‐DCR	6	436	Risk Ratio (IV, Random, 95% CI)	1.07 [0.98, 1.18]
2.2 EX‐DCR	8	473	Risk Ratio (IV, Random, 95% CI)	1.22 [1.11, 1.34]
3 Anatomic success, defined as patency to lacrimal irrigation at 6 months	4	306	Risk Ratio (IV, Random, 95% CI)	1.02 [0.95, 1.11]
3.1 EN‐DCR	1	76	Risk Ratio (IV, Random, 95% CI)	1.03 [0.84, 1.27]
3.2 EX‐DCR	3	230	Risk Ratio (IV, Random, 95% CI)	1.03 [0.93, 1.15]
4 Anatomic success, defined as patency to lacrimal irrigation at > 6 months	12	831	Risk Ratio (IV, Random, 95% CI)	1.09 [1.04, 1.15]
4.1 EN‐DCR	5	379	Risk Ratio (IV, Random, 95% CI)	1.06 [0.99, 1.14]
4.2 EX‐DCR	7	452	Risk Ratio (IV, Random, 95% CI)	1.12 [1.05, 1.20]