Ghosh 2006.

Methods	Study design: randomized controlled trial, parallel group Unit of analysis: participants Number randomized: 30 in total, 15 per group Number of arms: 2 Enrollment start year: 2003 Length of follow‐up: 12 months Sample size calculations: not reported Losses to follow‐up: not reported
Participants	Country: India Age (mean (SD)): 32.5 (NR) in total Females (n (%)): 20 (67) in total Inclusion criteria: recurrent epiphora for more than 2 to 4 months not responding to medical therapy Exclusion criteria: acute dacryocystitis, recurrent abscesses, tumors of the lacrimal apparatus Study group differences: not reported
Interventions	Intervention: EX‐DCR with application of 0.2 mg/mL MMC Comparison intervention: EX‐DCR alone
Outcomes	Measured outcomes: functional success, defined as the relief of epiphora anatomic success, defined as patency to lacrimal irrigation ostium size on nasal endoscopy postoperatively Adverse events: stenosis of the stoma, synechia
Identification	Author name: Soumitra Ghosh Institution: Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences Email: not reported
Notes	Funding source: not reported Declarations of interest: not reported Trial registration number: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No mention of how sequence generation was performed.
Allocation concealment (selection bias)	Unclear risk	No description of allocation concealment.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No description of masking of participants or personnel.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Masking of outcome assessors was not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants enrolled in the study were accounted for in the analysis.
Selective reporting (reporting bias)	High risk	Syringing performed, but no reporting of anatomic patency as a result. In addition, stoma and complaints of epiphora bound together as a combined outcome result.
Other bias	Unclear risk	There was insufficient information to permit a judgement of 'low risk' or 'high risk'.