Qiu 2000.

Methods	Study design: randomized controlled trial, parallel group Unit of analysis: eyes Number randomized: 92 in total, 48 to the MMC group, 44 to the DCR alone group Number of arms: 2 Enrollment start year: 1995 Length of follow‐up: 29 months Sample size calculations: not reported Losses to follow‐up: none
Participants	Country: China Age (mean (SD)): 29.6 (NR) in total Females (n (%)): 82 (89) in total Inclusion criteria: patients with chronic dacryocystitis Exclusion criteria: patients with upper lacrimal duct or nasal disorders, other systemic disorders Study group differences: no difference
Interventions	Intervention: DCR with application of 0.4 mg/mL MMC Comparison intervention: DCR alone
Outcomes	Measured outcomes: functional success, defined as the relief of epiphora anatomic success, defined as patency to lacrimal irrigation Adverse events: anastomotic bleeding
Identification	Author name: SK Qiu Institution: Department of Ophthalmology, Tengzhou Central Hospital Email: not reported
Notes	Funding source: not reported Declarations of interest: not reported Trial registration number: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Random sequence generation was not reported.
Allocation concealment (selection bias)	Unclear risk	Method of treatment allocation concealment was not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Masking of study participants and investigators was not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Masking of outcome assessors was not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data, participants were analyzed in the group to which they had been randomized.
Selective reporting (reporting bias)	Unclear risk	No trial or protocol registration available for comparison to ascertain selective outcome reporting.
Other bias	Unclear risk	There was insufficient information to permit a judgement of 'low risk' or 'high risk'.