Roozitalab 2004.

Methods	Study design: randomized controlled trial, parallel group Unit of analysis: participants Number randomized: 130 in total, 65 per group Number of arms: 2 Enrollment start year: 2001 Length of follow‐up: 6 months Sample size calculations: not reported Losses to follow‐up: none
Participants	Country: Iran Age (mean (SD)): 40 (15) in the MMC group, 42 (16) in the EX‐DCR group Females (n (%)): 89 (68.5) in total, 49 (75) in the MMC group, 40 (62) in the EX‐DCR group Inclusion criteria: diagnosis of nasolacrimal duct obstruction (congenital and acquired) Exclusion criteria: not reported Study group differences: no significant difference in age
Interventions	Intervention: EX‐DCR with application of 0.2 mg/mL MMC Comparison intervention: EX‐DCR alone
Outcomes	Measured outcomes: functional success, defined as the relief of epiphora anatomic success, defined as patency to lacrimal irrigation Adverse events: none
Identification	Author name: MR Namazi Institution: Shiraz University of Medical Sciences Email: Namazi_mr@yahoo.com
Notes	Funding source: not reported Declarations of interest: not reported Trial registration number: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of random sequence generation was not reported.
Allocation concealment (selection bias)	Unclear risk	Method of treatment allocation concealment was not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Masking of participants and personnel was not reported.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	All the examinations were done by the second author, who was masked to the procedures.
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were no missing outcome data.
Selective reporting (reporting bias)	Unclear risk	No trial or protocol registration available for comparison to ascertain selective outcome reporting.
Other bias	Unclear risk	There was insufficient information to permit a judgement of 'low risk' or 'high risk'.