CTRI‐2014‐09‐004989.

Methods	Randomized parallel‐group design
Participants	Inclusion criteria: 440 adult patients (> 18 years), presence of regurgitation on pressure over lacrimal sac and/or regurgitation admixed with mucopurulent debris on syringing, patients who have a hard stop on probing, normal eyelid function Exclusion criteria: patients undergoing revision DCR, pediatric patients (< 18 years), NLDO secondary to trauma, presence of any canalicular obstruction/eyelid condition responsible for epiphora, anemia (hemoglobin < 7 gram%) or deranged coagulation profile, presence of significant nasal pathology like deviated nasal septum, nasal polyps
Interventions	Intervention: mitomycin C injection (0.4 mg/mL): non‐endoscopic endonasal DCR with bicanalicular intubation with mitomycin C application at the ostium site Comparison intervention: no injection: non‐endoscopic endonasal DCR with bicanalicular intubation without mitomycin C application at the ostium site
Outcomes	Primary outcome: anatomical patency on syringing (time point: 6 months) Secondary outcome: anatomical patency Maximum follow‐up: 1 year
Notes	Start date: September 2014 Estimated end date: not reported