Table 1. Transporters involved in metformin pharmacokinetics.
Site | Transporter | Gene |
Gut (luminal) | Plasma monoamine transporter (PMAT) | SLC29A4 |
Gut (luminal) | Organic cation transporter (OCT3) | SCL22A3 |
Gut (basolateral) | OCT1 | SLC22A1a |
Liver | OCT1 | SLC22A1a |
OCT3 | SLC22A3 | |
Multidrug and toxin and extrusion (MATE1) | SLC47A1a | |
Bile/kidney (luminal) | MATE1 | SLC47A1a |
Kidney (basolateral) | OCT2 | SLC22A2 |
a. Genes of interest in this study.