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. 2020 Apr 2;30(Suppl 1):211–216. doi: 10.18865/ed.30.S1.211

Table 1. Transporters involved in metformin pharmacokinetics.

Site Transporter Gene
Gut (luminal) Plasma monoamine transporter (PMAT) SLC29A4
Gut (luminal) Organic cation transporter (OCT3) SCL22A3
Gut (basolateral) OCT1 SLC22A1a
Liver OCT1 SLC22A1a
OCT3 SLC22A3
Multidrug and toxin and extrusion (MATE1) SLC47A1a
Bile/kidney (luminal) MATE1 SLC47A1a
Kidney (basolateral) OCT2 SLC22A2

a. Genes of interest in this study.