Figure 2.

In women, gene transcripts previously shown to escape X chromosome inactivation (X chromosome inactivation) are important predictors of co-morbid CMSP and PTSS. A) Escape genes are over-represented in the list of 40 X chromosome (X chromosome) genes that significantly predict co-morbid CMSP and PTSS in women following motor vehicle collision. The pie chart on the left represents the proportion of all X chromosome genes that have been shown to escape X chromosome inactivation (n=93, yellow wedge) out of the total number of non-PAR X chromosome genes (n=783); the pie chart on the right represents the proportion of genes that have been shown to escape X chromosome inactivation (n=11) out of the total number of X chromosome genes that predict CMSP and PTSS in women following motor vehicle collision. B) Schematic representation of the location of “EscapeSet” genes on the X chromosome. C) Results of competitive gene set analyses indicate that EscapeSet genes are more differentially expressed in women who develop co-morbid CMSP and PTSS vs recover following motor vehicle collision than ^aX chromosomeSet genes, ^bany other set of nine X chromosome genes, and ^cany other set of nine randomly selected genes from the full transcriptome. ^dDirection of expression of genes in women who developed co-morbid CMSP and PTSS relative to expression of the same genes in women who recover following motor vehicle collision (i.e. “Up” indicates the genes are higher expressed in women with co-morbid CMSP and PTSS). D) Network analysis results based on EscapeSet genes using Ingenuity design software (IPA, Qiagen).