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. 2020 Mar 25;12(6):4711–4726. doi: 10.18632/aging.102673

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Copyright © 2020 Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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XIST knockdown restores sensitivity of NSCLC cells to DDP. (A, B) XIST expression levels analyzed by qPCR in normal or DDP-resistant NSCLC cells transfected with si-XIST or si-nc (control siRNA). (C) Cell proliferation analysis (MTT) results and quantification of DDP inhibition in A549 and H1299 cells. (D) Viability assay results for NSCLC cells treated with various concentrations of DDP. (E) Viability assay results for XIST-overexpressing A549/DDP and H1299/DDP cells treated with various concentrations of DDP. (F) Apoptosis analysis of XIST knockdown effects in NSCLC cells exposed to DDP. * < 0.05 vs si-nc group.