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. 2020 Mar 25;12(6):4711–4726. doi: 10.18632/aging.102673

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Copyright © 2020 Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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XIST silencing inhibits NSCLC growth in vivo. (A) A xenograft nude mouse model was established using A549 cells transfected with si-XIST, si-SMAD2, or their combination. (B) Tumor volume measurements. (C) Tumor weight measurements. (D) A xenograft nude mouse model was established using A549/DDP cells transfected with si-XIST and subjected to DDP treatment. (E) Tumor volume measurements. (F) Tumor weight measurements. (G) IHC analysis of the expression of apoptosis (cyto-c, bax, bcl-2, and caspase-3) and pyroptosis (NLRP3, caspase-1, IL-1b, and IL-18) markers in excised tumor samples. * < 0.05 vs control or si-nc group, ^# < 0.05 vs DDP or si-XIST group.