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. 2020 Apr 7;9:e53582. doi: 10.7554/eLife.53582

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© 2020, Miyamoto et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 8. — (A) Model of synthesis pathways of OAHFAs and their derivatives. Meibum lipids are shown as simplified structures (red, ω-OH FA; orange, FAl; blue, fatty diol). (B) Model of lipid polarity gradient formation by meibum lipids in the TFLL. CEs and WEs, which have the lowest polarity among meibum lipids, form the nonpolar lipid sublayer that faces the external environment. OAHFAs, phospholipids (PLs), cholesterol, and triglycerides (TGs) form the amphiphilic lipid sublayer that contacts the aqueous layer. Chl-OAHFAs and WdiEs are located at the interface between these two sublayers and have a role in connecting them.