. 2020 Apr 7;9:e53898. doi: 10.7554/eLife.53898

Table 2. Estimated half-maximal inhibitory concentrations (IC₅₀) of TTX for each Na_v1.6 construct.

IC₅₀ values are shown as the concentration (mean ± SEM) of TTX (µM) that blocked half of the channels, estimated from the dose-response curve. The IC₅₀ ratio was taken as the fold increase in TTX resistance.

Construct	N	IC₅₀	IC₅₀ Ratio
Mouse Na_v1.6	21	1.25 ± 0.09	1
DI (Y371A)	17	763.7 ± 284	609
DIII (V1407I)	13	2.34 ± 0.23	1.2
DIV (I1699V)	15	4.73 ± 0.42	2.0
Triple mutant	20	3551 ± 469	2832.4

Table 2. Estimated half-maximal inhibitory concentrations (IC50) of TTX for each Nav1.6 construct.

Table 2. Estimated half-maximal inhibitory concentrations (IC₅₀) of TTX for each Na_v1.6 construct.