Table 2.

The Targets of miR-34a identified in GICs

Cancer	Function			References
	Proliferation and Differentiation	Migration and Invasion	Treatment and Chemoresistance
EC	BCL2, CCND1, CCNE2, CDK4, CDK6, E2F3, MYCN, PLCE1, SIRT1	FNDC3B, MMP2, MMP9, YY1		[17,37,38,44,45]
GC	MET, PCBP2, PDGFR, SIRT7	CDK6, E2F3, MYC, TGIF2	HK1, MET	[51,52,54–56,60,61,69,71,75]
CRC	E2F5, FMNL2, HMGB1, CDK4, CDK6, CCNE2, E2F3, BCL2	IL-6R, JAG1, NOTCH1, SIRT1, STAT3, SNAIL, ZEB1, SLUG, ZNF281, MET	BCL2, E2F3, LDHA, NOTCH1, NOTCH2, SIRT1, SMAD4, ATG4B, DAPK1, SP1	[97–99,102–110,112–118]
HCC	FOXM1, HDAC1, MYC, TLR4	MET, SNAIL	BCL2	[130,135,138,140,144,148]
PC	NOTCH1, XIST, CD44, CDK6	SLUG, SNAIL, ZEB1	BCL2, CCND1, E2F1, MYC, SIRT1	[154,159,161–163,166–168]
GBC	PNUTS			[173]